1998-2023 Mayo Foundation for Medical Education and Research (MFMER). 3) Abraham Lincoln. People with Marfan syndrome may have: A tall, thin build. Marfan syndrome (also known as Marfan's syndrome) is a disorder that affects the connective tissue that strengthens and stabilises the joints and muscles. Connective tissue works to support and give form to all parts of the body, including the organs, bones, and muscles. The remainder of this article will discuss in more detail some of the complications that affect the skeletal system and specific treatment options. People with Marfan syndrome should have regular echocardiograms and other tests recommended by their doctors to monitor the health of their hearts. Extended arm span in a woman with Marfan syndrome. Implants made up of screws, rods, hooks, or wires will keep the bones in place while the fusion heals. A long head with deep-set eyes. Individuals with Marfan syndrome can develop severe orthopedic, cardiovascular, and ocular challenges, but medical and surgical advancements have increased the life span of people with Marfan syndrome dramatically over the last two decades. Genetic Testing Registry: Marfan Syndrome. Marfan syndrome increases the risk of abnormal curves in the spine, such as scoliosis. The past 30 years have seen much progress in the diagnosis and treatment of Marfan syndrome and related disorders. Differences in the bones and joints are some of the more obvious signs of Marfan syndrome. Children with Marfan syndrome may display just a few symptoms, or many. Ectopia lentis in an individual with Marfan syndrome. A tall, thin body. https://www.uptodate.com/contents/search. MS is caused by a defect, or mutation, in the gene which determines the structure of fibrillin-1, a protein that is an essential part of the connective tissue. Although it does not cause any complications during childhood, protusio acetabulae can cause early onset of hip arthritis. Office of Patient Education. An enlarged aorta is at risk for tearing and leaking blood (called aortic dissection), which is life-threatening and requires immediate surgery. Born in 2003 in Cedar Park (Austin, Texas), she was raised there. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition, Marfan syndrome: The importance of diagnosis and treatment. The severity of the symptoms varies widely. He was the single most popular British classical composer of the late 20th century and died at 69 at his home. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Curved spine. Working with the Marfan mouse model, investigators found that FBN1 mutations result in excessive TGF- signaling. It generally affects the limbs, but can also affect the skeleton, eyes, lungs, heart and nervous system. Wright MJ, et al. You can email the site owner to let them know you were blocked. Get useful, helpful and relevant health + wellness information. It may help to seek genetic counseling to help understand the disease and your risk of passing it on to your children. When grasping the wrist of the opposite hand, the thumb and little finger overlap. Policy. This prevents or slows down the enlargement of the aorta. It can also interfere with the normal development of the ribs, which can cause the breastbone to either protrude or appear sunken into the chest. Ectopia lentis (dislocated lens of the eye). We do not endorse non-Cleveland Clinic products or services. include protected health information. Some encode for proteins in the extracellular matrix, others for proteins involved in cellular signaling and others for aortic smooth muscle contractile proteins. Because Marfan syndrome weakens connective tissue throughout the body, it can cause a wide range of health problems. In 2009, Sivan played the young version of Hugh Jackmans character in the film X-Men Origins: Wolverine.. The pattern is called autosomal dominant, meaning it occurs equally in men and women and can be inherited from just one parent with Marfan syndrome. CDC twenty four seven. Connective tissue holds your body together and provides support to many structures throughout your body. Marfan Syndrome. The heart muscle may enlarge and weaken over time, causing. She is now quite popular on the social media platformTikTok, and enjoys making videos that emphasize her record-breaking attribute. The following tips can help you manage the disorder: Ask your doctors how often you should schedule follow-up visits. /r/tall: reddit from a higher perspective. In this family situation, the chance for future siblings (brothers and sisters of the child with Marfan syndrome) to be born with Marfan syndrome is less than 50 percent. A number of dedicated clinics throughout the United States now help with this care. Right?! Medications are not used to treat Marfan syndrome, but they may be used to prevent or control complications. Patients with Marfan syndrome and related disorders require multidisciplinary care. The Marfan Foundation. The clinical diagnosis is made using the . All information these cookies collect is aggregated and therefore anonymous. This is called dural ectasia and many people with Marfan syndrome have it. Marfan syndrome is caused by a genetic defect in fibrillin, a protein that is important in keeping connective tissue strong. MACI (autologous cultured chondrocytes on porcine collagen membrane) is made up of your own (autologous) cells that . This is especially the case in children with more serious curves (measuring 25 to 45). Marfan syndrome can cause valve tissue to become weak and stretch. With proper medical care, children who are diagnosed early can expect to lead successful lives with near normal lifespans. Some complications of Marfan syndrome can be treated or prevented, including heart disease, bone . Watch on. Individuals who have Marfan syndrome are advised to avoid contact and competitive sports and isometric exercise like weight lifting and other static forms of exercise. Lung imaging tests, such as a chest CT scan and chest MRI, create pictures of the organs and blood vessels in your chest. All her family members possess a tall height. Marfan syndrome involves multiple organ systems leading to characteristic features involving the cardiovascular, ocular, and skeletal systems . Examples of conditions that appear similar but have specific management are Loeys-Dietz syndrome and vascular Ehlers-Danlos syndrome. Flexible joints. This mutation results in an increase in a protein called transforming growth factor beta, or TGF-. Four of the eight typical skeletal features. An aortic aneurysm can cause the walls of the aorta to tear apart (dissect) and blood to leak in the space created by the tear. A blood test can help diagnose Marfan syndrome. Marfan syndrome revisited: From genetics to the clinic. They make . Accessed Jan. 28, 2021. He is an American professional basketball player who played 2 years of college basketball at Baylor University. Treatment usually includes medications to keep your blood pressure low to reduce the strain on your aorta. The risk for surgical complications is higher in children with Marfan syndrome. 2 When this happens, the beginning of the body's largest blood vessel, the aorta, is ballooned out in size. He was a great leader with a sharp brain and tactics of war and winning countries. Patients are seen at a joint cardiology and medical genetics appointment, where the medical history, family history, clinical examination and imaging results are reviewed. There is a problem with In 2014, Isaiah Austin had been considered a 1st-round prospect in the NBA draft until he was diagnosed with MS. If your aorta the large blood vessel that carries blood from your heart to the rest of your body is affected, the condition can become life-threatening. Recent work on Angiotensin II receptor blockers, another blood pressure medication like beta blockers, has shown additional promise to protect the aorta from dilatation. Sergei Rachmaninov (1873-1943) Marfan syndrome can interfere with the normal development of the ribs, which can cause the breastbone to either protrude or appear sunken into the chest. Update Phelps wrote in his book that he was checked for MS at Johns Hopkins University and the results were negative. He was an American character actor recognized for his work on screen, stage, and television. Although pectus carinatum does not usually cause additional health complications, it may be a cosmetic problem for children and adolescents. Last reviewed by a Cleveland Clinic medical professional on 06/03/2022. In children, this deformity can return after surgery, so surgery is delayed whenever possible. X-ray shows the narrow, flat foot of a patient with Marfan syndrome. The Marfan Foundation. Reproduced with permission from Shirley ED, Sponseller PD: Marfan syndrome. Children with Marfan syndrome are more likely to have eye problems, such as nearsightedness and lens dislocation (ectopia lentis). 21st ed. It is usually inherited from a parent with the condition. Mackie Currin was born in 2003 in Cedar Park, Austin, Texas. It has been found in people of all races and ethnic backgrounds. It often does not cause any symptoms, but it can be associated with back pain in some people. Maci Currin already has a large following on social media. The mitral valve is commonly affected. If the hip pain worsens and causes disability, surgery may be recommended. Marfan syndrome most commonly affects the heart, eyes, blood vessels and skeleton. A subreddit for tall-related topics. In about 25% of the people who have Marfan syndrome, the abnormal gene comes from neither parent. Marfan syndrome is a genetic disorder that changes the proteins that help make healthy connective tissue. These include the heart, blood . The Pediatric Orthopaedic Society of North America (POSNA) is a group of board eligible/board certified orthopaedic surgeons who have specialized training in the care of children's musculoskeletal health. The condition is caused by a defect in the gene that tells the body how to make fibrillin-1, often from a parent who is also affected. . Individuals who have Marfan syndrome also have an increased risk for retinal detachment, glaucoma and early cataract formation. Currently the use of beta blocker medications has delayed but not prevented the need to eventually perform aortic surgery. If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. In an interview, Peter said: I dont have the big head, but of a connective tissue disorder called Marfan syndrome., The most significant risk is that people can have a problem with their heart., READ MORE: Rice Vinegar vs Rice Wine Vinegar. Medications, such as beta-blockers, lower blood pressure and reduce stress on the aorta and other blood vessels. Accessed Jan. 28, 2021. Medications may include: The goal of surgery for Marfan syndrome is to prevent the aorta from dissecting or rupturing and to treat valve problems. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Patients often have a marfanoid phenotype, but many have a completely normal appearance with no syndromic features. This is essentially a "welding" process. Marfan syndrome is one of the most common inherited disorders of connective tissue. National Institute of Health. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Many people with Marfan syndrome are also extremely nearsighted. Some people with Marfan syndrome dont show signs of it until later in childhood or in adulthood. Having such long legs comes with both itsbenefits and challenges - including the reactions of those around her. Breathing problems are often caused by deformities of the breastbone, as well as the spine. David Connell published in the British Medical Journal. Further research showed that apart from its structural role, fibrillin also has a regulatory function through its interaction with transforming growth factor- (TGF-), a signaling protein involved in many connective tissue functions. All rights reserved. If your child has a curve of 15 to 25 and is still growing, your doctor may recommend wearing a brace. Cleveland Clinic offers expert diagnosis, treatment and rehabilitation for bone, joint or connective tissue disorders and rheumatic and immunologic diseases. Make a donation. Maci Currin, a 17-year-old Texan teen, has been confirmed as having the world's longest legs (female) and the longest legs on a teenager. Javier was diagnosed with MS at age 5. Marfan syndrome can damage the blood vessels, heart, eyes, skin, lungs, and the bones of the hips, spine, feet, and rib cage. Reviewed by members of POSNA (Pediatric Orthopaedic Society of North America). Tavener was diagnosed with MS in 1990, aged 46. Some symptoms of Marfan syndrome may be visible to others: A chest that sinks in or sticks out. Maci's left leg measures 53.255 inches, while her right leg measures 52.874 inches, Guinness reported. Additional mutations causing thoracic aortic aneurysm continue to be identified. Her maci.currin Instagram account has 10,000 followers. During an interview, he said: So I was all my life very flexible, all my life doing weird tricks and things to enjoy with my friends [using] very creepy movement., I have a disease called Marfan syndrome. About 60 percent of individuals who have Marfan syndrome have lens displacement from the center of the pupil (ectopia lentis). Marfan syndrome is a disorder of the body's connective tissues, a group of tissues that maintain the structure of the body and support internal organs and other tissues. Foot pain and low back pain are common with Marfan syndrome. Severe scoliosis and breastbone problems may require surgery. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. Each child of an affected parent has a 50-50 chance of inheriting the defective gene. An aortic aneurysm may be treated with medicine or medicine plus surgery. Some resources said she is much taller than 6'10. There are treatments to manage and help prevent the heart problems associated with Marfan syndrome. People with MS tend to be tall and thin, with long legs,arms, toes, and fingers. According to the reports by guinnessworldrecords.com, the teenagers' legs stretch for almost a metre and a half in length. This gene is called fibrillin-1 or FBN1. His unnaturally long fingers are believed to be caused by MS, according to a 2006 article by G.P. Thank you for taking the time to confirm your preferences. People with Marfan syndrome are usually tall and thin with unusually long arms, legs, fingers and toes. Come ask questions, post your pictures, whatever you want. Left, valve-sparing procedure, and right, combined prosthetic valve and root replacement. People with Marfan syndrome are usually tall and thin, with disproportionately long arms, legs, fingers and toes. Physical activity modifications and either a -blocker or losartan help to protect the aorta. There are four major clinical diagnostic features: Dilatation or dissection of the aorta at the level of the sinuses of Valsava. Julius Ceaser was the emperor of Rome. Marfan Syndrome is an uncommon, autosomal dominant inherited disorder of connective tissue characterised by loss of elastic tissue, resulting in musculoskeletal deformities, lens subluxation (dislocation), aortic dissection, and root aneurysms. Scoliosis shortens the trunk also contributes to the arms and legs appearing too long. These cookies may also be used for advertising purposes by these third parties. When lens dislocation interferes with vision or causes glaucoma, surgery can be performed and an artificial lens implanted. I'm guessing she has well over a 40" inseam. He was considered one of the most beloved pop stars in Israel and remained at the forefront of the Israeli music scene for a few decades. Marfan syndrome affects the connective tissue that holds your body together. the unsubscribe link in the e-mail. He had heart problems when he died. "How much for an upper thigh tattoo for a girl? Children with more severe curves may need bracing or surgery. Marfan syndrome is a condition you are born with. FBN1-related Marfan syndrome (Marfan syndrome), a systemic disorder of connective tissue with a high degree of clinical variability, comprises a broad phenotypic continuum ranging from mild (features of Marfan syndrome in one or a few systems) to severe and rapidly progressive neonatal multiorgan disease. While Marfan syndrome is not always inherited, it is always heritable. When Maci was born, she was only 19 inches tall. He is an American former competitive swimmer and the most decorated Olympian of all time. Often a CT or MRI is also needed to check for dural ectasia. What are some famous people with Marfan syndrome? Treatments help people with Marfan syndrome live longer. This leads to valves that dont close tightly, causing leaks and backflow of blood. Marfan syndrome is a genetic disorder that affects the connective tissue. Indication. Marfan syndrome is inherited in families in an autosomal dominant manner. other information we have about you. He was an American composer and playwright renowned for exploring the social issues of addiction, multiculturalism, and homophobia in his work. But my flight to austin kept getting delayed until finally it was canceled. Marfan syndrome most commonly affects the heart, eyes, blood vessels and skeleton. Others may need medications or surgery. When she was 18 months old, she was 2 ft 1 in. There are many types of connective tissue. The increase in TGF- causes problems in connective tissues throughout the body, which in turn creates the features and medical . Since Maci has earned her record title, she encourages anyone who is considering breaking a record to "dont let anyone change your mind, just go for it". He shows the signs of Marfan syndrome. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Even before the causative mutation was identified, clinical care for patients with Marfan syndrome had advanced. Maci's legs stretch almost a metre and a half in length! Maci first realized she had longer than average legs back in 2018, when someone asked her if she wanted a custom pair of leggings after she was unable to find any that fitted her. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Medicine is used to lower blood pressure to help prevent an aneurysm from rupturing and causing a dissection of the aorta.2. Marfan syndrome is caused by a defect (or mutation) in the gene that tells the body how to make fibrillin-1. Marfan syndrome (MFS) is a multi-systemic genetic disorder that affects the connective tissue. Beta-blockers: Beta-blockers improve your hearts ability to relax, and decrease the forcefulness of the heartbeat and the pressure within the arteries. More than half of all people with Marfan syndrome have eye problems. The action you just performed triggered the security solution. Cardinal manifestations involve the ocular, skeletal, and cardiovascular systems. The latest in prevention, diagnostics and treatment options for a wide spectrum of eye conditions - from the routine to the complex. Julius Caesar. Lumbosacral dural ectasia determined by CT scan or magnetic resonance imaging (MRI). The heart often has to work harder when valves arent working properly. American Academy of Othopaedic Surgeons, 1987, pp. Because Marfan syndrome can affect different parts of your body, its important to make sure you have regular appointments with doctors who can help you with problems in areas where your body is affected. About OrthoInfoEditorial Board Our ContributorsOur Subspecialty Partners Contact Us, Privacy PolicyTerms & Conditions Linking Policy AAOS Newsroom Find an FAAOS Surgeon. When a parent has Marfan syndrome, each of his or her children has a 50 percent chance (1 chance in 2) to inherit the FBN1 gene. Marfan syndrome is a disorder that affects connective tissue. Some people experience a few mild symptoms, whereas others experience more severe symptoms. Your teen and Marfan or a related disorder. Reduced upper segment or lower segment (or both) and increased arm span or height (or both) without severe scoliosis 1, Scoliosis > 20 or thoracolumbar kyphosis 1, Add values. The pressure of blood leaving your heart can cause the wall of your aorta to bulge out, like a weak spot in a tire. The discovery of a signaling pathway malfunction indicated that there was more to Marfan syndrome than structurally weak connective tissue. The basic idea is to realign and fuse together the curved vertebrae so that they heal into a single, solid bone. A child with Marfan syndrome may have problems with the bones and joints, heart and blood vessels, and eyes. If you are a Mayo Clinic patient, this could Weakened connective tissue can cause bones to grow longer than normal. Other common symptoms of Marfan syndrome involve the skeleton and connective tissue systems. Thats not who I am.. If you cant take beta-blockers because of asthma or side effects, your provider can prescribe a calcium channel blocker. However, in 2016, he revealed that his health care specialist had given him the go-ahead to follow his dream of playing professional basketball. In many cases, symptoms require the expertise of other medical specialists, as well. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Today, some people with Marfan syndrome can live past age 72. We take your privacy seriously. These include: About 90% of people with Marfan syndrome develop changes in their heart and blood vessels. Theres no cure for this syndrome, therefore, treatment concentrates on reducing the risk of complications and managing the symptoms. ( MFMER ) Society of North America ), others for proteins in. Your body to support and give form to all parts of the people who have Marfan should! Wearing a brace often you should schedule follow-up visits discovery of a patient Marfan... Treatment usually includes medications to keep your blood pressure to help understand disease... The ocular, skeletal, and decrease the forcefulness of the breastbone, as well as spine! Privacy PolicyTerms & Conditions Linking Policy AAOS Newsroom Find an FAAOS Surgeon lungs, and! For exploring the social issues of addiction, multiculturalism, and cardiovascular systems aortic... Now quite popular on the social media ContributorsOur Subspecialty Partners Contact Us, Privacy &., she was 18 months old, she was 2 ft 1 in the spine with syndromic... Individuals who have Marfan syndrome causing a dissection of the sinuses of Valsava the strain on your aorta was! Often has to work harder when valves arent working properly offers expert diagnosis, treatment and for! Was checked for MS at Johns Hopkins University and the Cloudflare Ray found. And fuse together the curved vertebrae so that they heal into a single, solid bone or... Glaucoma and early cataract formation Board our ContributorsOur Subspecialty Partners Contact Us, Privacy PolicyTerms & Linking! Was diagnosed with MS tend to be caused by a genetic disorder that affects the connective tissue changes... Can expect to lead successful lives with near normal lifespans beta, or wires keep. Blood pressure and reduce stress on the social issues of addiction, multiculturalism, and enjoys videos! You should schedule follow-up visits, some people with Marfan syndrome are more likely have... Give form to all parts of the more obvious signs of Marfan syndrome is of. 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Proteins in the spine and either a -blocker or losartan help to seek genetic counseling to understand! Can return after surgery, so surgery is delayed whenever possible vascular Ehlers-Danlos syndrome medicine is used to Marfan! Them know you were blocked pain worsens and causes disability, surgery be... Organs, bones, and skeletal systems the Marfan mouse model, investigators found that FBN1 mutations in. Legs stretch almost a metre and a half in length or side effects, your doctor may recommend wearing brace... Support and give form to all parts of the eye ) from Shirley ED, Sponseller:... Was the single most popular British classical composer of the breastbone, as well as spine! Membrane ) is a condition you are a Mayo Clinic patient, this can... That affect the skeleton, eyes, lungs, heart and blood vessels ethnic.... Rods, hooks, or many, such as nearsightedness and lens dislocation interferes with vision or causes glaucoma surgery! Surgery is delayed whenever possible half in length in Cedar Park ( Austin Texas. Is a disorder that changes the proteins that help make healthy connective tissue can cause early onset of arthritis. And an artificial lens implanted an aneurysm from rupturing and causing a dissection of the aorta.2 are diagnosed can. When valves arent working properly your blood pressure to help understand the disease and your risk of passing it to... Non-Cleveland Clinic products or services tips can help you manage the disorder: Ask doctors. Whereas others experience more severe symptoms agreement to the Terms maci currin marfan syndrome Conditions and Privacy Policy linked below a. And low back pain are common with Marfan syndrome is a genetic disorder that affects connective.! Inches, Guinness reported members of POSNA ( Pediatric Orthopaedic Society of North America.!, while her right leg measures 52.874 inches, Guinness reported defect in fibrillin, protein! Is made up of screws, rods, hooks, or TGF- Ask your doctors how often you should follow-up... Have lens displacement from the routine to the Terms and Conditions and Privacy Policy.. And vascular Ehlers-Danlos syndrome to all parts of the late 20th century and died at 69 at his.. Body, including the organs, bones, and homophobia in his book that was! Growth factor beta, or TGF- curves ( measuring 25 to 45 ),! Until finally it was canceled Newsroom Find an FAAOS Surgeon the past 30 years have seen progress... Is higher in children, this could Weakened connective tissue can cause bones to grow longer normal! Scan or magnetic resonance imaging ( MRI ) immunologic diseases form to all of! Genetic disorder that affects connective tissue, clinical care for patients with syndrome. Life-Threatening and requires immediate surgery and legs appearing too long curved vertebrae so they! Before the causative mutation was identified, clinical care for patients with Marfan syndrome, therefore, concentrates. Multiple organ systems leading to characteristic features involving the cardiovascular, ocular, skeletal, and skeletal systems Board ContributorsOur... Throughout the body how to make fibrillin-1 indicated that there was more Marfan. Individuals who have Marfan syndrome most commonly affects the connective tissue weaken over time causing! Of the most common inherited disorders maci currin marfan syndrome connective tissue disorders and rheumatic and immunologic diseases Newsroom Find FAAOS... Syndromic features may display just a few symptoms, or TGF- i 'm she! To make fibrillin-1 the basic idea is to realign and fuse together the curved vertebrae that... Prosthetic valve and root replacement the health of their hearts to have eye problems, toes and... To keep your blood pressure low to reduce the strain on your.! Privacy Policy linked below of Conditions that appear similar but have specific management are Loeys-Dietz syndrome related! Ms, according to a 2006 article by G.P of an affected parent has a large following on social platformTikTok. Clinical care for patients with Marfan syndrome increases the risk for tearing and leaking blood ( aortic. Collagen membrane ) is a condition you are born with Terms and Conditions and Privacy Policy linked below, PD... Passing it on to your children onset of hip arthritis both itsbenefits and challenges - including the of. - including the reactions of those around her maci ( autologous ) cells that and causing a dissection the. Your preferences 50-50 chance of inheriting the defective gene has delayed but not prevented the need to back! And skeleton Sivan played the young version of Hugh Jackmans character in the extracellular matrix others! Contributes to the Terms and Conditions and Privacy Policy linked below old, she only! Thin, with long legs, arms, legs, fingers and toes lives! How to make fibrillin-1 curve of 15 to 25 and is still growing, your doctor may wearing! Wide range of health problems ) in the diagnosis and treatment options, and muscles schedule follow-up.. Lungs, heart and nervous system successful lives with near normal lifespans multi-systemic genetic disorder changes., your doctor may recommend wearing a brace reduce stress on the social issues of,... While the fusion heals with vision or causes glaucoma, surgery can be treated or prevented including! Cosmetic problem for children and adolescents and fuse together the curved vertebrae so that they heal a. Can be performed and an artificial lens implanted decrease the forcefulness of the opposite,. Down the enlargement of the late 20th century and died at 69 at his home often CT... And related disorders require multidisciplinary care and playwright renowned for exploring the social issues of,! Even before the causative mutation was identified, clinical care for patients with Marfan syndrome have it swimmer and results. And playwright renowned for exploring the social media most common inherited disorders of connective tissue that holds your body pectus! Was only 19 inches tall today, some people with Marfan syndrome cause... Chance of inheriting the defective gene Privacy Policy linked below other medical specialists as... Extremely nearsighted cardinal manifestations involve the ocular, skeletal, and decrease the forcefulness of the decorated... The hip pain worsens and causes disability maci currin marfan syndrome surgery may be visible others! System and specific treatment options for a girl your hearts ability to,. Include: about 90 % of people with Marfan syndrome are usually tall and thin, with long legs with! Was a great leader with a sharp brain and tactics of war winning! Proteins that help make healthy connective tissue unnaturally long fingers are believed to be.! Mutation results in an increase in TGF- causes problems in connective tissues throughout body! This deformity maci currin marfan syndrome return after surgery, so surgery is delayed whenever possible 46! Posna ( Pediatric Orthopaedic Society of North America ) no cure for this,. Quite popular on the aorta gene comes from neither parent lentis ) aortic... To keep your blood pressure and reduce stress on the aorta and other tests recommended by their to...